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Hidradenitis suppurativa is a common recurrent inflammatory skin disease, which is underdiagnosed by physicians. Severe disease is associated with multiple comorbidities, but mild disease with fewer symptoms has been poorly investigated. This study of otherwise healthy blood donors with self-reported hidradenitis suppurativa symptoms and their registry data on drug prescription, found that people with symptoms of mild hidradenitis suppurativa had 1.73 times the risk of depression and 1.24 times the risk of needing pain medication compared with healthy controls. As people with even mild hidradenitis suppurativa are at risk of pain and depression, clinical practice should increase its focus on diagnosis of this disease.