All-Cause Mortality Among Patients with Hidradentitis Suppurativa: a population-based cohort study in the United States.



Mortality risk for patients with hidradenitis suppurativa (HS) is largely unknown.


To compare mortality risk among patients with and without HS in the United States.


Retrospective cohort study in a population sample identified using electronic health records data between January 1, 2012 and December 31, 2016. Primary outcome was incidence of 5-year all-cause mortality.


Crude 5-year mortality rate among HS patients was 2.4% (321/13,289), compared to 2.7% (18,508/685,573) among controls. In the fully adjusted model, increase in HS mortality risk was 14% [OR 1.14, 95% CI 1.01-1.28]. Overall, excess risk of death attributable to HS was 3.1 deaths per 1,000 patients (95% CI 0.2 – 6.0) during the study period. Characteristics associated with mortality among HS patients included age (OR 1.05, 95% CI 1.04-1.06), male sex (OR 1.40, 95% CI 1.09-1.79), ever smoking status (OR 1.48, 95% CI 1.16-1.92), and CCI score (OR 1.25, 95% CI 1.21-1.29).


Follow-up period may not have been long enough to assess influence of disease severity or duration on mortality.


HS appears to confer an independent risk of all-cause mortality. This risk is also influenced by tobacco smoking and comorbidities, which may be modifiable.

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